Buffalo Bills @ New Orleans Saints

Odds: Buffalo -6.5, over/under 45

Weather: Dome conditions

Highlighting the three game Thanksgiving slate is a matchup between the 6-4 Buffalo Bills and the 5-5 New Orleans Saints. Buffalo is coming off a 41-15 home loss to the Indianapolis Colts, which dropped them to second place in the AFC East. New Orleans is coming off a 40-29 loss to the Philadelphia Eagles, extending their losing streak to three.

Buffalo is struggling, losing two of their last three, and Josh Allen’s MVP chances have taken a big hit. Allen is averaging 315.1 yards passing per game with 21 touchdowns and 8 interceptions. He also averages 34 rushing yards per game with another three rushing touchdowns. Wide receiver Stefon Diggs is Allen’s favorite target, hauling in 60 of 92 passes for 773 yards and six touchdowns. Cole Beasley has been a reliable target, bringing in 57 of 74 targets for 484 yards and one touchdown. Emmanuel Sanders is second on the team in receiving with 531 yards on 33 receptions with four touchdowns. Tight end Dawson Knox has been one of Allen’s favorite redzone targets with 28 receptions for 383 yards and five touchdowns.

Devin Singletary leads the rushing attack with 415 yards on 83 carries with two touchdowns. Allen is second with 340 yards. Zach Moss has rushed for 265 yards on 75 carries with four touchdowns.

With Alvin Kamara out, New Orleans is missing a major part of their offense. Kamara has totaled 840 yards on the ground and through the air. Newly acquired running back Mark Ingram is a reliable veteran, but he’s nowhere near the game-breaker Kamara is. Ingram has rushed for 205 in four games since re-joining New Orleans, adding 132 yards through the air on 17 receptions.

Trevor Siemian and Taysom Hill are handling the quarterback duties after Jameis Winston was lost for the season with a knee injury. Siemian is averaging 234.5 yards passing per game with 8 touchdowns and 2 interceptions. No receiver in particular has stood out this season with Deonte Harris leading the wide receiving corp in receptions with 26 and 418 yards and two touchdowns. Marquez Callaway leads the team in receiving touchdowns with six. He has 25 receptions for 372 yards. Tre’Quan Smith missed five games and has 16 receptions for 205 yards and two touchdowns.

Injury report:

Out:

Buffalo: None

New Orleans: RB Alvin Kamara (knee), T Ryan Ramczyk (knee), DE Marcus Davenport (shoulder)

Questionable:

Buffalo: None

New Orleans: DE Tanoh Kpassagnon (ankle) OUT; RB Mark Ingram (knee), OL Terron Armstead (knee, shoulder)